Orthopaedic Research and Clinical Trials
The Department of Orthopaedic Surgery’s distinguished history is grounded on Johns Hopkins Medicine’s principle that laboratory research and bedside teaching need to coexist in the instruction and practice of medicine. The creation of a formal Research Division and the Center for Musculoskeletal Research in 2009 provided a nexus for basic and translational research related to the musculoskeletal system.
Learn More About
Clinical Trials
For a complete list of available clinical trials, search the database at the Johns Hopkins Institute for Clinical and Translational Research. You can search by condition, researcher or doctor’s name.
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Summary: A study of MACI in patients aged 10 to 17 years with symptomatic chondral or osteochondral defects of the knee (PEAK).
Objective: To evaluate an experimental treatment for knee cartilage defects called membrane-induced autologous chondrocyte implantation (MACI).
Principle Investigator: R. Jay Lee, M.D.
Eligibility Criteria: Children age 11-17 with knee cartilage defects
Contact: Gabrielle Richard ([email protected])
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Summary: A Post-Market, Prospective, Multi-Center, Open-Label, Single Arm Clinical Evaluation of the Integra TitanTM Modular Shoulder System 2.5 for Primary Shoulder Joint Replacement (IRB00169712).
Objective: To evaluate 2-year implant survivorship in subjects who receive the TSS-2.5 when used for primary shoulder arthroplasty.
Principle Investigator: Umasuthan Srikumaran, M.D., M.P.H., M.B.A.
Eligibility Criteria: Candidate for total shoulder arthroplasty.
Contact: Sanjana Vattigunta (443-516-1550 or [email protected])
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Summary: A study of MACI in patients aged 10 to 17 years with symptomatic chondral or osteochondral defects of the knee (PEAK).
Objective: Evaluate overall pain medication consumption following surgical treatment for shoulder pathology
Principle Investigator: Umasuthan Srikumaran, M.D., M.P.H., M.B.A.
Eligibility Criteria: Opioid-naive adults age 18-90 years old planning to undergo surgical treatment for shoulder pathology with Dr. Uma Srikumaran.
Contact: Sanjana Vattigunta (443-516-1550 or [email protected])
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Objective: Improve health care for patients with chronic lower back pain (LBP) and increase the likelihood that patients obtain outcomes that matter most to them.
Principle Investigator: Richard Skolasky, Sc.D.
Eligibility Criteria: Adults age 18 - 64 years old, meets NIH Task Force definition of chronic LBP, had a healthcare visit for LBP in the past 90 days and have moderate levels of pain and disability.
Contact: Tricia Kirkhart (410-502-4453 or [email protected])
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Objective: To evaluate the combined effect of botulinum toxin A (administered as Dysport®) and bracing in children with adolescent idiopathic scoliosis.
Principle Investigator: Paul D. Sponseller, M.D.
Eligibility Criteria: Diagnosed with AIS, 10 to 16-year-old children.
Contact: Vivian Tran and Varun Puvanesarajah (410-955-3136 or [email protected])
Participants in this study will be compensated.
Featured Research Stories
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Alum Establishes Annual Lecture on Diversity in Medicine
Anita Rao, one of the first women to complete a sports medicine fellowship in the Johns Hopkins Department of Orthopaedic Surgery, shows gratitude for her training through an endowed lectureship supporting diversity.
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Estate Planning Offers a Lasting Chance to ‘Give Back’
Michael Feinstein and his wife, Sharon, are making a financial gift in recognition of his fulfilling work with the Johns Hopkins Department of Orthopaedic Surgery.
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Paradigm Shift: Patient Optimization Before Elective Arthroplasty
A recent review by Johns Hopkins orthopaedic surgeon Harpal Khanuja and colleagues found that it helps to give intravenous iron to patients who are very anemic, and in elective surgery cases, anemia should be treated before the patient has the procedure.
Our orthopaedic research division and its faculty members are recognized internationally as leading innovators in musculoskeletal science and training. Our investigators conduct basic, translational and clinical research in topics that represent the great diversity of problems that impact the musculoskeletal system. Focus areas include integrative musculoskeletal biology, stem cells and regenerative medicine, skeletal neurobiology, bone metastasis and clinical outcomes.
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Komatsu Lab
Malfunction and malformation of blood vessels are associated with a broad range of medical conditions, including cancer, cardiovascular diseases, and neurological disorders. The ultimate goal of the Komatsu lab is to find a way to reverse the process of abnormal vessel formation and restore normal function to these vessels. In cancer, normalization of tumor blood vessels facilitates lymphocyte infiltration, potentiating anti-tumor immunity, and enhances the efficacy of immunotherapies as well as conventional cancer treatments. Normalization of regenerating blood vessels is also necessary for reestablishing blood flow to ischemic hearts and limbs, and preventing blindness caused by diabetic retinopathy or macular degeneration. Komatsu lab’s research is uncovering key molecular pathways important for the normalization of pathological vasculature.
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Spine Outcomes Research Center
The Spine Outcomes Research Center is a multidisciplinary group committed to improving patient outcomes and applying high-quality and purposeful research to professional practice. The organization values collegial interaction and strong scientific principles.
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Zhou Lab
In the Zhou Lab, the overall goal of our research is to understand the molecular mechanisms underlying development of the mammalian nervous system. Specifically, we are interested in understanding how neurons generate their complex morphology and form proper circuitries during development and how neurons regenerate to restore connections after brain or spinal cord injuries.
Recent Publications
Genetic counseling and testing for hereditary hemorrhagic telangiectasia.